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Promotive Effect of Human-derived Neurotrophin-6 on the Survival of Cultured Hippocampal Neurons
Cheng-Wu Zhang, Li-Li Cao1, Huo-Zhen Hu1, Yu Zheng*
Department of Physiology, West China School of Preclinical and Forensic Medicine, Sichuan University, Chengdu 610041, China; 1Department of Biology, School of Life Sciences, Sichuan University, Chengdu 610041, China
Abstract: The hippocampus of P7 SD rat was isolated. The hippocampal neurons were cultured with the culture medium added mature peptide of human-derived neurotrophin-6. The surviving hippocampal neurons were counted at different time of culture after neuron-specific enolase immunohistochemical staining. It was shown that the number of surviving hippocampal neurons in the experimental group of neurotrophin-6 was significantly increased. This study indicated that the human-derived neurotrophin-6 could enhance the survival of the cultured neurons， suggesting its nutritious and protective action on the nervous system.
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