MCLK and ROCK Influence on Cytoskeleton and Cell Behaviors

Abstract: Myosin light chain kinase and Rho kinase are two major enzymes controlling myosin light chain (MLC) phosphorylation in both muscle cells and non-muscle cells. MLC phosphorylation is the key reaction to regulate myosin contraction， which involved in many vital progresses， such as cell migration， adhesion， tissue repair， cancer metastasis and disease development etc. Although both of these two kinases could phosphorylate MLC and regulated cytoskeleton reorganization， there are distinct differences between their special location and the way to regulate cell function precisely by the cytoskeleton arrangement.

CSTR: 32200.14.cjcb.2009.04.0002