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Asymmetric Cell Division
Zheng-Jun Pan, Zhong-Ke Chen*
Institute of Developmental Biology, School of Life Science, Shandong University, Jinan 250100, China
Abstract: Asymmetric cell division is the foundation of multicellular organism development. The characteristics of asymmetric cell division are asymmetric segregation of cell fate determinants into one of the two daughter cells. Asymmetric cell division proceeds through four steps: first， an axis of polarity is established. Second， the mitotic spindle is set up and oriented along this axis of polarity. Third， cell fate determinants are distributed in a polarized fashion along this axis. Fourth， different concentrations of these determinants in the two daughter cells lead to the establishment of distinct cell fates after cell division.
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