Advances in the Research of Nasal Organoids and Nose-on-a-Chips
ZHENG Hairui, LI Qi, ZHAO Yunteng, LIU Rong, WEI Jinyan, LI Gang*
The nasal mucosa, as the first line of defense in contact with the external environment for the respiratory system, plays a crucial role in disease prevention and treatment. However, traditional in vitro models havevarious limitations and fail to meet the urgent demands of modern medical research. With the rapid development ofbiomedical technology, the construction of nasal organoids and nose-on-a-chip provides more accurate and reliablemodels for studying the pathological processes and pathogenesis of nasal-related diseases. This article provides acomprehensive review of the research progress achieved in the areas of physiological model construction, diseasemodeling, drug screening, and clinical applications of nasal organoids and nose-on-a-chip, hoping to provide a reference for the development and application of nasal organoids and nose-on-a-chip.
CN
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