Progress of Exercise in Prevention and Treatment of Parkinson’s Disease through Striatal Astrocyte EAATs
ZHOU Wenhui*, LI Gangqiang
PD (Parkinson’s disease) is the second most common neurodegenerative disease and occurs mainly in middle-aged and elderly people. Degeneration and loss of dopaminergic neurons in the SNpc (substantia nigra pars compacta) of the midbrain leads to a large reduction in DA (dopamine) release to the BG (basal ganglia) striatum, resulting in excessive Glu (glutamate) energy signal transduction in the striatum associated with PD progression, while EAATs (excitatory amino acid transporters) on striatal astrocytes can regulate Glu clearance and therefore become a potential target for the treatment of PD. Exercise intervention, as an adjunct to PD, can effectively alleviate PD-related behavioral dysfunction, and the mechanism may be mediated by regulating EAATs expression levels in striatal astrocytes. This article reviews the research on the role of striatal astrocyte EAATs in PD neurodegeneration and exercise prevention and treatment of PD, in order to provide necessary theoretical basis and new ideas for the study of neurobiological mechanism of exercise intervention in relieving PD-related behavioral dysfunction and targeted intervention.
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