Factors and Signaling Pathways Related to microRNA Regulation of Tumor Formation

HUANG Lingwei^1,2, ZHANG Zhenyu^1,2, WANG Jiamin^1,2,3, QIAO Zilin^1,2,3, AYIMUGULI Abudureyimu^1,2, YANG Di^1,2,4*

(¹Gansu Tech Innovation Center of Animal Cell, Biomedical Research Center, Northwest Minzu University, Lanzhou 730030, China;²Engineering Research Center for Key Technologies and Industrialization of Cell-Based Vaccines, Ministry of Education, Biomedical Research Center, Northwest Minzu University, Lanzhou 730030, China;³Key Laboratory of Bioengineering and Technology State Ethnic Affairs Commission, Biomedical Research Center, Northwest Minzu University, Lanzhou 730030, China;⁴Department of Experiment & Teaching, Northwest Minzu University, Lanzhou 730030, China)

Abstract:

miRNA (microRNA) acts as a single-stranded non-coding RNA that inhibits the expression of protein coding genes through binding to the untranslated regions of target mRNA. Previous research has established that miRNA can regulate tumor formation through some factors such as ceRNA, exosomes and environment. The majority of miRNA exhibites regulatory effects on essential processes of tumor cells, including proliferation, apoptosis and autophagy, cell cycle, cell migration and invasion, energy metabolism and so on. Thus, miRNAs has emerged as a promising biomarker for targeted-tumor therapy. This article undertakes an in-depth review of the signaling pathways linked with miRNA regulationg of tumor formation, with a particular focus on the interplay among JAK/STAT3, Wnt/β-catenin and PI3K/AKT pathways. By providing a sound basis for understanding the mechanisms involved in tumor genesis and development, this article aims to lay the groundwork for discovering new tumor treatment pathways and cancer therapy targets.

CSTR: 32200.14.cjcb.2023.06.0016