The Toxicological Effects of Arsenic Trioxide on Monopterus albus

Abstract: To study the toxicological effects of the different dosages of As₂O₃ on Monopterus albus. The methods of the mutagenesis test and red and white blood cells counting in fish were used to assay the white cell number， micronuclei and nuclear abnormity of red cell in peripheral blood erythrocytes， and CAT activity of liver in Monopterus albus. Results show that the rate of micronuclei and the rate of nuclear abnormity， and CAT activity gradually increase， white cell number gradually decrease， in rang of lower dosage. At 0.50 mg/kg they are respectively the highest and the lowest. With the dosage continuing to increase， the frequency of micronuclei and nuclear abnormity of red cell， and CAT activity decrease instead， white cell number gradually increase. The experiment enunciates that the some dosage of As₂O₃ can effect on erythrocytes and leucocyte of peripheral blood， and CAT activity of liver in Monopterus albus.
    

CSTR: 32200.14.cjcb.2006.04.0027