Research Progress in Innate Immune Memory of Macrophages
ZHANG Dongyue, ZHENG Guoguang*
Based on the mechanisms and characteristics of immune effects, immunity is usually divided into innate immunity and adaptive immunity. For a long time, it has been generally believed that only adaptive immunity has memory characteristics. Recent studies have shown that innate immunity also has memory phenomenon. Stimulated innate immune cells acquire memory properties through epigenetic reprogramming and cell metabolic change, which enable them to have enhanced or suppressed response against secondary stimulation. This phenomenon is termed as “trained immunity” or “innate immune memory”. Macrophages, the important innate immune cells, also have immune memory properties and play an important role in immune system. Innate immune memory is a new concept, which broadens the definition of immune memory and provides a more comprehensive perspective for the study of immune response. This paper mainly reviews the characteristics, mechanism and role of macrophage innate immune memory in diseases.
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