The Role of Autophagy in Alzheimer’s Disease
SHI Yating, YAO Zhaoyang, ZHANG Wei*
AD (Alzheimer’s disease) is a neurodegenerative disease with cognitive dysfunction, which is mainly characterized by SP (senile plaque) formed by Aβ (β-amyloid protein) deposition and NFTs (neurofibrillary tangles) formed by hyperphosphorylation of Tau protein in cells. Autophagy is an important way to effectively remove abnormal proteins in nerve cells and maintain organism homeostasis. In this review, relevant studies on autophagy and AD in recent years have been retrospected, as well as the basic process of autophagy and the relationship between autophagy and AD are summarized in detailly and systematically. In addition, this review deeply explores the regulation of autophagy-related pathways and its role in AD, and expects to provide a scientific and reasonable theoretical basis for the prevention and treatment of AD.
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