Application of Organoid Model in Prostate Research

LIU Zhuang¹^#, YU Bo²^#, YU Chen³, GAO Dong¹*

(¹State Key Laboratory of Cell Biology, Shanghai Key Laboratory of Molecular Andrology, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, Shanghai 200031, China; ²School of Biological Engineering, Daqing Normal College, Daqing 163712, China; ³Shenzhen Bay Laboratory, Shenzhen 518132, China)

Abstract:

PCa (prostate cancer) is the most common cancer in males in Western countries, and its incidence is increasing in China. The studies of prostate cell fate regulation are critical for PCa diagnosis and therapy. However, prostate research is hampered by the lack of suitable cell models. In recent years, the emerging organoid culture technology has brought revolutionary changes to the field of stem cell and tumor research, which has greatly promoted the progress of prostate research. This review summarizes the application of organoid culture technology in prostate stem cell and PCa research, discusses its advantages and disadvantages, and looks forward to the future directions of organoid culture technology.

CSTR: 32200.14.cjcb.2021.06.0005