Progress in the Study of Endometrial Stem Cell
Zhuang Pan1, Liu Junquan1,2*
The human endometrium which formed by the fusion of mesoderm tissues in the process of embryonic development is one of the most active tissues in human metabolism and self-renewal. It is located between the myometrium and uterine cavity and divided into three layers: compact layer, spongy layer and basal layer. The basal layer is closest to the myometrium, which is not affected by the periodic changes of ovarian sex hormones and does not fall off during menstruation. Endometrial stem cells are undifferentiated endometrium cells with self-renewal, multidirectional differentiation and high proliferation potential. Numerous studies have demonstrated that endometrial stem cells are involved in endometrial repair and regeneration and can improve the symptoms of specific diseases; the occurrence of various gynecological diseases is related to its abnormal biological behavior. This article reviews the progress in the definition, basis, origin, separation methods, biological characteristics and clinical application of endometrial stem cells.
CN
EN