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The Correlation between Wnt/β-catenin Signaling Pathway and Henoch-Schonlein Purpura in Children
Li Xiu, Zhang Xiaocui, Zhang Hongli, Zhao Qixing, Deng Fang*
Department of Pediatrics, The First Affiliated Hospital of Anhui Medical University, Hefei 230022, China
Abstract: This study was to observe the expression of Wnt/β-catenin signaling pathway in children with Henoch-Schonlein purpura (HSP). The expression of HSP and the possible role of the signaling pathway in HSP were discussed. Immunohistochemical method was used to detect the renal tissue in children with HSP and Henoch-Schnlein purpura nephritis (HSPN). The 24 h urine protein in children with HSPN was correlated with the expression of Wnt4， β-catenin and E-cadherin. The results of immunohistochemical staining showed that the expression of Wnt4 and β-catenin in the skin of the HSP group was significantly higher than that in the normal control group (P<0.01)， and the expression of E-cadherin was significantly lower than that in the normal control group (P<0.01). In the renal tissue of children with HSPN， the expression of Wnt4 and β-catenin was significantly increased (P<0.01) in the normal control group (P<0.01)， mainly in the renal tubules， and the expression of E-cadherin was significantly decreased than that in the normal control group (P<0.01). The kidney tissue of HSPN patients， the expression of E-cadherin was negatively correlated with the quantity of 24 h urinary protein (R=–0.695， P<0.05). The results suggest that Wnt4， β-catenin and E-cadherin are abnormal in the skin of HSP and the renal tissue of HSPN， and the expression of E-cadherin in renal tissue is associated with urinary protein. It is suggested that Wnt/β-catenin signaling pathway may be involved in the pathogenesis of HSP.
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