NIF3-like Superfamily Proteins

Abstract: NGG1p interacting factor 3 (NIF3)-like protein belongs to a protein superfamily which contains a NIF3 domain that is highly conserved from bacteria to mammals. The mRNAs which encode these proteins are ubiquitous in various kinds of species and tissues. However， due to that most of these proteins are presumed， there are few studies on their functions. So， they are called as "unknown proteins" The proteins of this super family are α/β proteins， and execute functions by forming dimers or complexes with other proteins. It has been demonstrated that this kind of proteins is involved in gene transcription and particularly plays an essential role in the mammal neurocyte differentiation. Recent studies indicated that NIF3-like proteins also related to some human diseases. Just because these NIF3-like proteins are abundant， ubiquitous and functionally unknown， more and more attentions were attracted to them.

CSTR: 32200.14.cjcb.2007.06.0007