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The Combinatorial Biosynthesis of Polyketide
Hui-Juan Huang, Jian-Jun Qiao*
School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, China
Abstract: Combinatorial biosynthesis has been accepted as a useful method to produce a larger number of "unnatural" natural products. And it also has received a great attention in innovation and application of new drugs in recent years. It is now feasible to generate biologically active compounds by combinatorial biosynthesis， and some progress has been made with polyketides. Depending on examples of the literature， this paper reviews the opportunities for increasing structural diversity among natural products by combinatorial biosynthesis. Some of the problems and limitations encountered with the approaches are also discussed.
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