Home > Browse Issues > Vol.37 No.11
Studies of Optogenetic Control of Intracellular Signaling Pathways
Nan Di1,2, Xu Yingke1,2*
1Department of Biomedical Engineering, Zhejiang University, Hangzhou 310027, China;
2Key Laboratory of Biomedical Engineering of Ministry of Education, Zhejiang Provincial Key Laboratory of Cardio-Cerebral Vascular Detection Technology and Medicinal Effectiveness Appraisal, Hangzhou 310027, China
2Key Laboratory of Biomedical Engineering of Ministry of Education, Zhejiang Provincial Key Laboratory of Cardio-Cerebral Vascular Detection Technology and Medicinal Effectiveness Appraisal, Hangzhou 310027, China
Abstract: Optogenetics combines genetic expression with optical controlling and imaging， which permits rapidly activation and regulation of the activities of intracellular signaling molecules. Optogenetics has great promise in cell biology applications. To date， a variety of photoactivatable modules have been identified. They have distinct structure and photoactivation features， and those have greatly extended optogenetics in the biomedical research. In this review， we will introduce different species of photoactivatable modules， their distinct photon properties， and with an emphasis on their applications in using light to control intracellular cell signaling.
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