Home > Browse Issues > Vol.37 No.9
ESDN Is A Multifunctional Type-I Transmembrane Protein
Li Weiwei, Nie Lei, Han Mei*
Department of Biochemistry and Molecular Biology, College of Basic Medicine, Key Laboratory of Medical Biotechnology of Hebei Province, Key Laboratory of Neural and Vascular Biology of Ministry of Education, Hebei Medical University, Shijiazhuang 050017, China
Abstract: Endothelial and smooth muscle cell-derived neuropilin-like molecule (ESDN) is one of type-I transmembrane protein that is genetically conserved among various mammalian species. It consists of a N-terminal secretory signal sequence， a CUB structural domain， a LCCL structural domain， a coagulation factor V/VIII homology domain and a long cytoplasmic tail. It is relatively conservative in the process of biological evolution. This ESDN molecule confer diverse and sophisticated functions， thus to modulate vascular remodeling， influence tumor metastasis， immune regulation， etc. The structure， distribution， as well as the affected physiological functions are summarized in this review.
CN
EN