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Immunoregulatory Effects of Purinergic P2 Receptors
Zhou Jinfeng1, Qin Chaoyan1, Lai Weiming1, Du Changsheng1,2*
1Shanghai Key Laboratory of Signaling and Disease Research, School of Life Sciences and Technology,Tongji University, Shanghai 200092, China;
2State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China
2State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China
Abstract: Purinergic P2 receptor is a kind of nucleic acid derivative receptor， it can regulate immune response when activated. The purinergic receptors play important roles in the modulation of proliferation，differentiation， apoptosis and migration of immune cells， as well as the secretion of cytokines and chemokines involved in inflammation. This article introduces the classification of the purinergic P2 receptors， the expression of purinergic P2 receptors on immune cells and their function in modulating immune response.
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