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Research Progress of Structure and Function of Importin
Guo Jianlin1, Xu Cunshuan1,2*
1State Key Laboratory Breeding Base for Cell Differentiation Regulation Co-sponsored by Henan & Ministry of Science and Technology, Xinxiang 453007, China;
2College of Life Science, Henan Normal University, Xinxiang 453007, China
2College of Life Science, Henan Normal University, Xinxiang 453007, China
Abstract: Importin is a class of conserved protein family that widely exists in eukaryotic organisms. The functions of importin are involved in the transport of cargo proteins including transcription factor， splicing factor，ribosomal protein and others into nuclei through nuclear pore complex. Importin contains subunit alpha and beta family， each has multiple members. Studies indicated that importin had significant relationship with the formation and development of regeneration， cancer， Alzheimer’s disease， foot and mouth disease and other diseases. This review focuses on the recent progress in the structure， functions of importin and the correlation with physiological and pathological activities.
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