The Effects of Copper Acetic Acid on Reproductive Toxicity of the Male Mice

Abstract: The sperm deformity test and PCE micronucleus test were used to study the different doses of copper acetic acid on reproduction toxicity of male mice. The copper acetic acid of 0.25-16.00 mg/kg/d were respectively investigated by intraperitoneal injection to male mouse for 7 days. The results show that the copper acetic acid in each experimental group can inhibit the increases of body weight and testis， of which group VI and VII are the most remarkable. They can also reduce significantly the vitality and concentration of sperm. There is an apparent dose-effect. Besides， the frequencies of sperm deformity and micronucleus in each experimental group are significantly higher than the control group抯. Moreover， they rise with increasing dose of copper acetic acid. The results show that experimental doses of copper acetic acid have obvious effects of reproduction toxicity on ICR male mice.
    

CSTR: 32200.14.cjcb.2007.03.0028