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Research Progress on Hippo Signaling Pathway in Female Reproductive System
Li Jia1,2, Zhou Fangyue1, Huang Jian1, Zheng Liping1*, Zheng Yuehui1,2*
1Medical Teaching Laboratory Center, Jiangxi Medical College, Nanchang University, Nanchang 310006, China;
2Life Sciences Institute, Nanchang University, Nanchang 310006, China
Abstract: The Hippo signaling pathway is a recently discovered signal transduction pathway in Drosophila and mammals， which is a broadly conserved and novel pathway comprised multiple of tumor suppressor genes and an oncogene. The Hippo pathway has complex characteristics and cross-linking dialogue with other signaling pathways. It has been accepted to play an important role in the regulation of organ size， cell cycle， apoptosis and maintenance of their homeostasis. Recent findings suggested that the Hippo pathway regulate female reproductive system development. Therefore， more and more researchers pay attention to Hippo pathway research in female reproductive system development and its application in disease treatment. In this study， we discussed the physiological characters and functions of Hippo pathway， and emphasized the regulation in female reproductive system， such as ovary， mammary gland， follicle， etc.
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