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Compartmentalized Regulation in Caveolae and Implications for Drug Design Strategies
Ling-Lin Fu* , Zi-Rong Xu, Rajeev K. Jha
College of Animal Science, Educational Ministry Key Laboratory of Molecular Animal Nutrition, Zhejiang University, Hangzhou 310029, China
Abstract: As specialized lipid rafts， caveolae are present on many types of mammalian cells， particularly on endothelial cells， adipocytes and smooth muscle cells. Recent studies mostly focus on compartmentalized regulation and physiological role of caveolae with the aim to develop novel drug delivery strategies. New techniques including gene knockout and fluorescence resonance energy transfer provide valuable tools for elucidating functions of caveolin as well as investigating signaling protein interactions in caveolae， which may benefit for drug design.
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