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The Effects of Notch Signaling Pathway on Neural Stem Cells Proliferation and Differentiation
Wang Jue1, Deng Yubin1*, Wan Yong2
1Research Center of Translational Medicine, the First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, China;2Department of Spine Surgery, the First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, China
Abstract: Neural stem cells (NSCs) have the ability of self-renew and multiple differentiations. The proliferation and differentiation of NSCs can be regulated by internal or external， adjacent or far-off cell signaling pathways. Recently， researchers indicated that Notch signaling pathway probably can deliver cell signal though receptors and ligands of adjacent cells and then impact NSCs morphology and their neural differentiation. Recent researches on the effects of Notch signaling pathway on NSCs proliferation and differentiation were reviewed in this paper.
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