Home > Browse Issues > Vol.35 No.12
Relationships Between Polarity Proteins and Epithelial Tumor Transformation
Gao Anding1, Liu Kuancan2, Lin Baoshun2, Lan Xiaopeng1,2*
1Fuzhou General Hospital Clinical Medical School, Fujian Medical University, Fuzhou 350025, China; 2Institute for Laboratory Medicine, Fuzhou General Hospital, PLA, Fuzhou 350025, China
Abstract: Cell polarity is the asymmetry of cell morphology， protein distribution and cell function. It is essential in many physiological processes， including cell development， wound healing， as well as maintenance of apical-basal cell polarity and tissue integrity， which is regulated by polarity proteins. Loss of the cell polarity will lead to tumorigenesis and metastasis. Studies have shown that aberrant expression and localization of polarity proteins are closely related with human tumors， particularly in epithelial tumors. Loss of cell polarity and the tissue disorganization are commonly observed in epithelial tumor transformation. After epithelial-mesenchymal transition， epithelial tumor cells are more easily to invade the surrounding matrix， and eventually form metastases. In this study， the current data that the role of polarity proteins in cancer are reviewed， focusing on the function of polarity proteins in tumor metastasis.
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