Home > Browse Issues > Vol.35 No.12
AGR2: A New Biomarker of Cancer Diagnosis
Wei Longgang, Deng Mingtao, Zhao Yinan, Lü Zhongxian*
School of Pharmaceutical Sciences, Xiamen University, Xiamen 361005, China
Abstract: AGR2 is a secreted protein and widely found in the prostate， breast， lung and pancreatic gland tissue. It has excessive expression in the tumor tissue of these glands and regulates tumor cell survival， growth and metastasis. Clinical expression of AGR2 in breast cancer， prostate cancer and pancreatic cancer is relative to the progress of tumor development. Thus， AGR2 is considered to be a promising biomarker for early diagnosis and prognosis. In this paper， we reviewed the current research status of AGR2， especially tumor related functions， clinical investigation and mechanisms.
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