Home > Browse Issues > Vol.35 No.2
Structure and Function of Proprotein Convertases
Wu Wenfeng1#, Zhang Juanhui2#, Tang Songshan1*
1Biochemistry and Molecular Department, School of Basic Courses, Guangdong Pharmaceutical University, Guangzhou 510006,China; 2Center of Reproduction & Infertility, Department of Obstetrics & Gynecology, Guangdong Provincial Corps Ho
Abstract: Precursors of polypeptide and protein hormones are maturated through the processings of
proprotein convertases， and/or carboxypeptidase， amidation enzyme. Proprotein convertases play the most important
role in the process. Proprotein convertases consist of nine endoproteases with Ca2+-dependent endopreolysis
activity， which is closely correlated with many physiologic processes， i.e. the maturations of peptide and protein
hormones， membrane receptors， and some viral proteins etc. They also are closely correlated with many diseases，
i.e. cancer， cerebral apoplexy， diabetes， and lipid metabolism disorder. The structure and function of proprotein
convertase is reviewed in the article.
proprotein convertases， and/or carboxypeptidase， amidation enzyme. Proprotein convertases play the most important
role in the process. Proprotein convertases consist of nine endoproteases with Ca2+-dependent endopreolysis
activity， which is closely correlated with many physiologic processes， i.e. the maturations of peptide and protein
hormones， membrane receptors， and some viral proteins etc. They also are closely correlated with many diseases，
i.e. cancer， cerebral apoplexy， diabetes， and lipid metabolism disorder. The structure and function of proprotein
convertase is reviewed in the article.
CN
EN