Home > Browse Issues > Vol.34 No.7
Advance on Self-renewal Regulation of Mammalian Spermato-gonial Stem Cells
Gao Yongfu, Yang Siqiang, Liu Dan, Yu Shumin*
College of Veterinary Medicine, Sichuan Agricultural University, Yaan 625000, China
Abstract: Spermatogonial stem cells (SSCs) possess both self-renewing division and differentiating division functions， the balance of the two functions not only maintains the stem cell number stable but also meets the demand of the testis to produce millions of sperms each day. Recently， because of the establishment and perfection on techniques of culture in vitro， genetic engineering and germ cell transplantation， the largest break-through in selfrenewal regulation mechanism of SSCs has already been made， including the new discoveries of protein regulatory factors， MicroRNA and the DNA methylation. The present review mainly focuses on the protein regulatory factors such as extrinsical cytokines and specific endogenous transcription factors controlling the SSCs self-renewal， which purposes to provide ideas on the mammalian SSCs.
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