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Expression of CCNG2 in Gastric Carcinoma and Its Relationship with Prognosis
Shi Wei1, Yu Kanru1, Wu Guoying2, Zhang Hao1*
1Affilied Huashan Hospital of Fundan University, Shanghai 200040, China; 2Affilied the 3th Hospital of Zhejiang Chinese Medical University, Hangzhou 310009, China
Abstract: In order to investigate CCNG2 expression and determine its clinical significance in gastric carcinoma， tissue microarray blocks containing tumor specimens from 225 patients were constructed. Expression of CCNG2 in these specimens was analyzed using immunohistochemical detection. The expression of CCNG2 was observed in 115 cases (55.1%) of 225 primary tumors. CCNG2 expression was significantly inversely associated with advanced T stages， lymph node metastases， advanced disease stage， and poor histological differentiation. Loss of CCNG2 expression significantly correlated with poor survival both in univariate and multivariate analyses. Our results showed that CCNG2 could be involved in the development and progression of gastric cancer. CCNG2 expression could be as a biomarker for progression of gastric cancer.
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