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Morris Water Maze in the Analysis of Mouse Phenotype
Wei-Gang Wang1, Jia-Bin Zhou2, Ming-Li Zhu2, Ying-Han Wan2, Hui-Min Yan2*
1School of Life Science and Technology, Tongji University, Shanghai 200092, China;2Shanghai Research Center for Model Organisms, Shanghai 201203, China
Abstract: This article presented the basic protocal of the Morris water maze. MWM is widely used to study spatial learning and memory in the rodents. Animals are put into the pool of opaque water where they are trained to escape to a hidden platform in the navigation of visually distinct cues for 6 days (acquisition). At the 7 th day， the platform was removed. Animals will search for the missing platform (retention). A good performance in the learning and memory test was established in both strains. C57 mice showed better performances in the trail. Taken together， MWM plays an important role in the analysis of mouse phenotype.
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