Research Advances on cGAS-STING Pathway Regulation of Cellular Senescence and Tumorigenesis

WANG Miao^1,2, WANG Xianjue^1,2, YANG Zhiqing^1,2, LIANG Yabing^1,2*, YANG Ling^1,2*

(¹Central Laboratory of the Affiliated Hospital of Inner Mongolia Medical University, Hohhot 010050, China; ²Key Laboratory of Medical Cell Biology of Inner Mongolia Autonomous Region, Hohhot 010050, China)

Abstract:

The cGAS (cyclic guanosine monophosphate-adenosine monophosphate synthase)-STING (stimulator of interferon genes) pathway, a central component of innate immunity, regulates cellular senescence and tumorigenesis by detecting cytoplasmic DNA. Recent research has demonstrated that this pathway plays a critical role in modulating both cellular senescence and tumor development. This review systematically examines the bidirectional regulatory relationship between the cGAS-STING pathway and cellular senescence, and it elucidates the dual roles of this interplay in tumorigenesis. These analyses thereby provide a rationale for developing novel antitumor strategies that target this pathway to influence cellular senescence.

CSTR: 32200.14.cjcb.2026.02.0026