Roles of Epigenetics in Regulating Ferroptosis in Tumor Cells
GUO Honghao#, ZHANG Yingru#, CHI Keke, SUN Jianwei*, YU Zhouliang*
Epigenetics refers to the reversible and heritable regulation of gene expression and phenotypic traits without altering the underlying DNA sequence. This regulation is mediated through mechanisms such as DNA methylation, histone modifications, and non-coding RNAs. In recent years, as their broad involvement in biological processes and potential in drug development have been increasingly recognized, epigenetic regulation has become a research hotspot. Ferroptosis is a novel form of cell death dependent on lipid peroxidation and iron ions. Recent research indicates that various epigenetic mechanisms—including DNA methylation, RNA methylation, histone modifications, and non-coding RNAs—play critical roles in regulating ferroptosis in tumor cells. They affect the expression of ferroptosis-related genes, modulate cellular sensitivity to ferroptotic induction, and consequently influence tumor development and progression. Furthermore, abnormal epigenetic regulation is an important factor contributing to drug resistance in tumor cells. This review aims to summarize recent advances in the epigenetic regulation of ferroptosis, providing a theoretical basis for understanding its mechanisms, exploring new targeted therapies, and inspiring innovative approaches in tumor treatment.
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