Systemic Mechanisms of Injury Response: Toward a “Leverage Points”in Regenerative Medicine
HAN Yu1, ZHANG Hui2*
The tissue injury response is a fundamental capacity for maintaining homeostasis, with regeneration being the optimal outcome. Traditional research has focused on localised repair, inadequately considering the dynamics of the entire organism within the complex system. This review takes a systems-level approach, proposing that the injury response is a trans-scale, multi-tiered, dynamically coordinated programme. By revealing principles at the organ level following injury and identifying key regulatory nodes—the programme's underlying leverage points—this framework establishes new theoretical foundations and intervention strategies for regenerative medicine.
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