The Manufacture and Application of Three-Dimensional Mesenchymal Stromal Cell Microtissue

The efficiency of transplanted mesenchymal stem cell is generally low due to lack of oxygen and nutrient supply in clinical trials. This problem can be improved by aggregating stem cells into three-dimensional microtissues. This article elucidated the problems associated with the fabrication and application of three-dimensional microtissues, with particular attention to the possibility of further transfering these findings into clinical application.