Home > Browse Issues > Vol.32 No.2
Control of Tumor-related-microRNA Gene Expression by Epigenetic Mechanisms
Jun-Ming Guo*, Bing-Xiu Xiao, Jiu-Chang Zhong
Ningbo University School of Medicine, Ningbo 315211, China
Abstract: Epigenetics is defined as the heritable changes in gene expression without any alteration in DNA sequence. MicroRNAs (miRNAs) are small RNA molecules of approximately 22 nucleotides in length. They negatively regulate gene expression in posttranscriptional level. Recently， miRNAs have been definitively linked to cancer development. And their expression profiles can be used to classify human cancers. Despite the growing evidences for miRNAs?importance in carcinogenesis， little is known about the expression-regulation mechanisms of their genes. Based on the considering the relationships among epigenetics， miRNAs and tumors， this review introduces the progresses of the epigenetic control of gene expression of miRNA， mainly including DNA methylation and histone modification.
CN
EN