Home > Browse Issues > Vol.32 No.2
The Effect of KiSS-1 Gene on Tumor Metastasis
Xiao-Cui Zhang, Fu-Min Yin, Wei Zhang*
Key Laboratory for the Cell Proliferation and Regulation Biology, Ministry of Education, Beijing Normal University, Beijing 100875, China
Abstract: KiSS-1 gene， initially described as the melanoma metastasis suppressor gene， encodes a number of peptides. Recent data suggests that the products of KiSS-1 play an important role in tumorgenesis and metastasis as well as in the regulation of the reproductive system. As a tumor metastasis suppressor gene， the expression of KiSS-1 is precisely regulated. KiSS-1 can regulate the transcription of the matrix metalloproteinase (MMPs) through the NF-kB pathway and negatively regulates chemotactic responses mediated by CXCR4. In this scenario， it is important to decipher the function and mechanism of the KiSS-1 gene. KiSS-1 can act as a marker to evaluate the progression of cancer. It may be used as a novel molecular target in cancer therapy.
CN
EN