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The Relationship between Nuclear Factor-kB and Malignant Disease
Jing Li1, Xin Liu1,2, Qing-Wei Li1 *
1Institute of Marine Genomics & Proteomics, Liaoning Normal University, Dalian 116029, China; 2College of Urban and Environmental Science, Liaoning Normal University, Dalian 116029, China
Abstract: Nuclear factor-kB (NF-kB) is an important transcriptional factor. It exists in most kinds of cells involving gene regulation of many physiological and pathological processes. NF-kB system consists of NF-kB family and its inhibitor nuclear factor-kB inhibitor (IkB) family. The mechanism of anti-apoptosis can induce carcinogenesis such as renal tumor， prostate cancer， stomach cancer， colorectal cancer， colon cancer， breast cancer. By inhibiting degradation of IkB can prevent NF-kB from activation， it also induces tumor cells apoptosis. Consequently we can inhibit the activity of NF-kB by gene therapy in accompany with conventional chemotherapy. This review comments on the role of NF-kB in the malignant diseases based on the latest research results domestic and abroad and prospect the study direction in the future.
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