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Effects of Inonotus obliquuss Fermentation Liquid Extraction on Different Cell Lines


Lan-Ying Wang, Fang Huang, Yan Su, Ai-Rong Song*
Shandong Provincial Key Laboratory of Applied Mycology, Qingdao Agricultural University, Qingdao 266109, China
Abstract: Fermentation liquid extraction samples of Inonotus obliquus抯 strains (IOFE) were initially chosen to test the cell activity in vitro using hominal抯 liver cancer cell line HepG2, the hominal抯 stomach cancer cell line SGC7901 and the normal hominal抯 liver cell HL-7702. The result indicated that the HepG2 and the SGC7901 could been inhibited in the low consistency, comparatively, the inhibition effect on SGC7901 was better than on HepG2; the extraction not only had no inhibition effect on the multiplication of the HepG2 and the SGC7901, but also had definite auxo-action; Although fermentation liquid extraction of Inonotus obliquus抯 strains had the lower inhibition effect on HepG2 and the SGC7901, it had the greatly repair effect on the postinjury HL-7702, and the repair function increased along with the strengthen of the concentration. In the high concentration 3 000 mg/ml, the repair rate was 303.01%. It followed that IOFE could be used as an antineoplastic ancillary drug to repair the greatly injury on patient by the chemotherapeutics in the treatment of oncotherapy.


CSTR: 32200.14.cjcb.2010.02.0022