Embryonic Stem Cell Transplantation Therapy in Parkinson's Disease

Abstract: Since the murine embryonic stem cells were isolated in 1981， embryonic stem (ES) cell can be harvested from the rodents， the rabbits， the swines and human. The first derivation report of human ES cell in 1998 provoked the field of human ES cell research. ES cell are derived of the inner cell mass of the early embryon， they can proliferate infinitely in vitro while retaining the ability to differentiate into all somatic cells. Although this field is only in its infancy， human ES cell represent a theoretically inexhaustible source of precursor cells that could be differentiated into any cell types to treat the degenerative diseases such as the diabetes， Parkinson's disease， Alzheimer's disease， spinal cord injury， heart failure， and bone marrow failure. In recent years， the therapy research of the Parkinson's disease using dopaminergic neuron derived of ES cell is extensively more and more. This review updates the gene expression， the progression of empirical study， the clinical application and the problems encountered of these researches. Although these researches has not be utilized in clinic in large areas， they provided a wide application perspective for the therapy of the Parkinson's disease.

CSTR: 32200.14.cjcb.2008.01.0001