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Variation in Cell Traction Force of Anterior Cruciate Ligament Stem Cells before and after Differentiation
De-Shun Ma*, Shu-Yun Gao, Chun-Xia Lu, Zheng-Xin Yi
School of Biological and Environmental Engineering, Shenyang University, Shenyang 110044, China
Abstract: Cell traction force (CTF) is an important physical parameter， which indicate a growth state of cells. In this study， Researcher have measured CTF of anterior cruciate ligament (ACL) stem cells before and after differentiation， and than found that CTF of ACL stem cells were decreased obviously after differentiation when these cells change significantly in morphology. The average of magnitude of CTF were reduced by 30%. The amount of a-smooth muscle actin (α-SMA) also be reduced correspondingly. This suggest that the structure and component of stem cells have changed significantly and to a certain extent the expression of a gene coding α-SMA have been inhibited.
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