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Bioinformatics Analysis of MACF1-related Proteins
Jia Liu, Zong-Cheng Tian, Ai-Rong Qian, Peng Shang*
Key Laboratory for Space Bioscience and Biotechnology, Institute of Special Environmental Biophysics,Faculty of Life Sciences, Northwestern Polytechnical University, Xi'an 710072, China
Abstract: Microtubule actin cross-linking factor1 (MACF1) is a kind of cytoskeleton crosslinking protein and combined with microfilaments and microtubules of cytoskeleton. MACF1 plays an important role in coordinating cell growth and maintaining integrity of tissue. The relationships among MACF1-related proteins were analyzied and classified by hpysicochemical characteristics， subcellular localization and molecular function. A protein-protein interaction networks were constracted according to the data of molecular function. The subcellular localization of 5 MACF1-related proteins were predicted. Network analysis results suggest that MACF1 possibly interact with SKIL or ATF7IP through competitive binding mechanisms， and participation in TGF-β signal transduction regulation， thereby affecting fibroblast phenotype changes. MACF1 also may transport vesicle by binding neuronal cell surface receptors， then promote the neuronal cell adhesion.
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