Home > Browse Issues > Vol.32 No.1
Differences of Proliferation Rate and ERa Expression between MCF-7 Cell Lines from Different Labs
Wei-Ru Xu1,2, Hong-Sheng Lin2*, Xin-Yi Chen1, Ying Zhang2
1Beijing University of Chinese Medicine, Beijing 100029, China; 2Oncology Department, Guang'anmen Hospital,China Academy of Chinese Medical Sciences, Beijing 100053, China
Abstract: There were obvious differences between two MCF-7 cell lines from different labs on the morphology and growth rate in vitro. The xenotransplantation of two MCF-7 cell lines into NOD/SCID mice were studied. The immunohistochemistry was investigated on the tumors， which showed the loss of human epidermal growth factor receptor 2 (Her2) in two cell lines， and the loss of estrogen receptor a (ERa) in one cell line. The results suggested that the increase of cell proliferation rate might be correlated with the loss of ERa in MCF-7 cell line.
CN
EN