Home > Browse Issues > Vol.32 No.1
Progress in Multilineage Potential Study of Bone Marrow Stromal Stem Cell
Xue-Jun Dong*, Sun He, Guo-Rong Zhang, Li-Xin Xiang1, Ruo-Lang Pan1,Ye Chen1, Rui-Peng Zhang1, Jian-Zhong Shao1
Molecular Medicine Center, Shaoxing People's Hospital, Shaoxing 312000, China; 1Key Laboratory for Cell and Gene Engineering of Zhejiang Province, College of Life Sciences, Zhejiang University, Hangzhou 310058, China
Abstract: Bone marrow stromal stem cells (BMSSCs) are one of the most favorable cells in adult stem cells. Not only they played an important role in the production and development of hemapoietic system and immune system， but also they had effects on the process of tissue regeneration and injury repair. Especially， recent research showed that BMSSCs had the capability of trans-differentiating into adult cells derived from different germ-layers. It might reveal the new mechanism of cells?differentiation based on this research model， and also it provided us a creative way on the tissue engineering with BMSSCs and clinical therapy. At present， BMSSCs have been confirmed to be able to differentiate into hepatocytes， neurocyte， cardiocyte， vascular endothelial cell and islet cell， besides differentiating into osteoblast， chondrocyte and adipocyte. In this review， we will mainly focus on the research progress on the plasticity mechanism of BMSSCs.
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