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Progress in Markers of Hair Follicle Stem Cells
Zhen-Hong Ni, Yong Shao, Yu-Hong Li1*
Team One of Students Brigade, Third Military Medical University, Chongqing 400038, China; 1Department of Cell Biology,College of Basic Medical Sciences, Third Military Medical University, Chongqing 400038, China
Abstract: Hair follicle stem cells (FSCs) located in the hair follicle bulge region are a group of adult stem cells which play a key role in periodic growth of hair follicle， renewal of epidermis and sebaceous gland and skin repair after injury. The markers of FSCs are necessary for the identification and separation of FSCs and critical for the basic research of FSCs. To find the better markers of FSCs has become a study hotspot in recent years. In this review we classify the makers to three types according to their distinct locations in the cells， one in the cell membrane， one in the cytoplasm and one in the nucleus. We focus on the frequently used markers such as integrin， keratin， CD34， CD200 and also introduce some novel ones including Lgr5， Sox9， Tcf3， and so on.
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