The Regulative Effects of NF-_kB Signaling Pathway on Cell Cycle

Abstract: Nuclear factor kB (NF-kB)， a member of the mammalian Rel protein family， is a heterodimer of p65 and p50， and is sequestered in the cytoplasm in the inactivated state through the ankyrin repeats of its specific inhibitor， IkB. NF-_kB undergoes nuclear translocation and binds to its decameric DNA response element (5'-GGGACTTTCC-3') when actived by its up-stream signal cascades. As a result， the transcription of NF-_kB regulation gene is stimulated. NF-_kB has been identified to play an important role in promoting inflammation and in regulating cell proliferation and survival. This review surveys our current understanding of the role of NF-_kB signaling pathway in regulation of the cell cycle， with focusing on its actions on cyclin， cyclin-dependent protein kinase (CDK) and CDK inhibitor， respectively， which lead to the transition of G₁/S and G₂/M phases.

CSTR: 32200.14.cjcb.2004.05.0013