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The Relationship between S100A4 Gene and Metastasis of Tumor Cells
Yang Bai, Min Kong, Jing-Ze Wang*
State Key Laboratory of Biomembrane and Membrane Biotechnology, Institute of Zoology, Chinese Academy of Science, Beijing 100080, China
Abstract: Metastasis is an important malignant character of tumor. Many genes and factors are involved in this process. Former studies found that S100A4 gene could participate in many vital cellular activities， including cell cycle control， cell proliferation and differentiation， angiogenesis， remodeling of the extracellular matrix. In some tumor cells， the expressive up-regulation of protein S100A4 is correlated with metastasis and oncogenesis. This article is written to provide some useful information for the study of the relationship between S100A4 gene and metastasis.
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