The Apoptosis and Hybrid Cell Death Induced by the Na⁺-K⁺-ATPase Blocking

Abstract: The Na⁺-K⁺-ATPase， sometimes called Na⁺ pump or Na⁺-K⁺ pump， is a transmembrane enzyme acting as an electrogenic ion transporter in the plasma membrane of all mammalian cells. The primary role of the Na⁺-K₊-ATPase is to maintain high intracellular K⁺ and low intracellular Na⁺. More importantly， accumulating evidence now endorses a close relationship between cellular K⁺ depletion and apoptosis. In some cell types， cellular K⁺ depletion induces a newly recognized "hybrid cell death" of concurrent apoptosis and necrosis in the same cells.

CSTR: 32200.14.cjcb.2004.05.0006