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Regulation of Downstream Target Genes of Transcription Factor Oct-4 and Its Relationship with Toti/pluripotency of Embryonic Development
Xiao-Feng Wan, Xiao-Li Zhao, Ming Zhang*
College of Life Sciences, Zhejiang University, Hangzhou 310012, China
Abstract: Scientists have made a great breakthrough in embryonic stem (ES) cell differentiation in vitro into dopaminergic (DA) neuron in the last several years， this is valuable in neuronal cell transplantation as well as the basic research of neurogenesis. This review focuses on ES cell in vitro being committed and differentiation into DA neurons by analysis and compare the methods， detect and cytokine of the differentiation， furthermore， discusses the current problems and development in future in this issue as well.
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