Regulation of Downstream Target Genes of Transcription Factor Oct-4 and Its Relationship with Toti/pluripotency of Embryonic Development

Abstract: As a transcription factor related to toti/pluripotency of embryonic development， Oct-4 activates or represses different target genes via diverse modulation mechanism， thereby plays important roles in regulation and maintenance of cell toti/pluripotent and undifferentiated state. Among the known target genes regulated by Oct-4， there are not only some important transcription factors， for example Rex-1， but also some genes participate in important cellular activities such as Fgf-4. So researches on regulation of downstream target genes of Oct-4 will help us to find out it's role in differentiation and development， and provide new insights into the understanding of toti/pluripotency and it's regulatory net in development

CSTR: 32200.14.cjcb.2004.05.0001