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Multicellular Resistance in Cancer Therapy and Three-dimensional Cell Culture
Qian Jia1,2, Shao-Bai Xue1, Mei-Fu Feng2*
1Key Laboratory of Cell Proliferation and Regulation of Ministry of Education, Institute of Cell Biology, College of Life Science, Beijing Normal University, Beijing 100875, China; 2State Key Laboratory of Biomembrane and Membrane Bi
Abstract: Multicellular resistance (MCR) phenomenon in cancer treatment is due to there is the three-dimensional structure for tumor inside the body. In recent years， MCR phenomenon has been studied by using three-dimensional cell culture technology in vitro. It was found that the mechanism of MCR is mainly related to three-dimensional structure itself， i.e. intrinsic resistance and contact resistance. In addition， some methods were found to be able to reverse or decrease MCR， which might be used in cancer treatment by oneself or united with others in the future.
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