Home > Browse Issues > Vol.26 No.4
X Chromosome Inactivation in Mammalian
Shi-Yong Xu, Hong-Lin Liu*
College of Animal Science and Technology, Nanjing Agricultural University, Nanjing 210095, China
Abstract: In mammals， equal dosage of X-linked genes between the sexes is achieved by X chromosome inactivation in a random or imprinted manner in early embryonic development of females. It is a complex process including initiation， counting， choice and maintenance. X inactivation center is the master control locus of the X chromosome inactivation and regulates the early events of X inactivation. Once the X inactivation happened the inactivation state can be stably delivered to generations. This involves genome imprinted. In addition， in males， the X chromosome is inactivated together with Y chromosome in spermatogenic cells shortly before or during early meiotic prophase. This article reviews the recent advances in X chromosome inactivation in mammalian.
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