Notch Signaling Pathway and Its Regulation

Abstract: The Notch receptor is an evolutionarily conserved single-span transmembrane protein family and plays key roles in a wide variety of cell fate decisions during development of both invertebrate and vertebrate species. An intriguing pathway of Notch signaling has been elucidated involving three-step proteolytic cleavages leading to activation of Notch. A number of molecules related and events in vivo have been identified to regulate Notch signaling. Regulation occurs at multiple levels including Notch-ligand interactions， trafficking of receptor and ligands， the cleavage of Notch intracellular， degradation of proteins by ubiquitination， and so on. This review focuses on the Notch receptor， Notch signaling pathway and its regulation at different levels.

CSTR: 32200.14.cjcb.2004.04.0010